Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer's Disease

Alzheimer'~ rfi o;ease is an age-related neurodegenerative disease and is characterized by the presence of senile plaques (SP), neurofibrillary tangles, and synapse loss. Amyloid-beta, one of the main components of SP, has been known to induce oxidative stress and is highly toxic. Using redox proteomics approaches a number of oxidatively modified proteins were identified in AD and mild cognitive impairment (MCI) brain that are consistent with the clinical presentation, pathology, and biochemistry. The identification ot key proteins that are highly susceptible to amyloid-beta-mediated oxidation might serve as biomarkers for use in diagnosing and also in the iden tification of therapeutic targets to prevent or delay this devastating disorder.